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Updated: Jun 15, 2026

Method of Direct Segmental Intra-hepatic Delivery Using a Rat Liver Hilar Clamp Model
Published on: April 2, 2017
Mitigating Lipopolysaccharide-Induced Hepatorenal Injury: The Role of Chrysin-Loaded Poly (Lactic-Co-Glycolic Acid)
Islam Ahmed Abdelmawgood1, Asmaa Elsayed Abdelkader1, Noha A Mahana1
1Zoology Department, Faculty of Science, Cairo University, Giza, Egypt.
Abstract:
Chrysin (CHR), a naturally occurring flavone recognized for its anti-inflammatory and antioxidant activities, exhibits medicinal properties; nevertheless, the clinical use is constrained by inadequate absorption and limited bioavailability. This research employed poly-lactic-co-glycolic acid (PLGA) as a nanodrug carrier to enhance the bioavailability, solubility, and effectiveness of CHR in protecting mice against lipopolysaccharide (LPS)-acute liver and kidney damage. CHR-loaded PLGA nanoparticles (CHR-NPs) were synthesized and analyzed. Mice were allocated into six groups (n = 8/group): control, LPS, Dexa (5 mg/kg), PLGA (50 mg/kg), CHR (50 mg/kg), and CHR-NP (50 mg/kg). CHR-NP improved liver and kidney function, alleviated histopathological abnormalities, and elevated enzymatic and non-enzymatic antioxidants while reducing iron deposition, lipid peroxidation, and proinflammatory mediators. Furthermore, the Keap1/Nrf2/HO-1 signaling pathway was upregulated after oral administration of CHR-NP. Through activating the Keap1/Nrf2/HO-1 signaling pathways, our data demonstrate that CHR-NP significantly alleviated acute liver and kidney injury by inhibiting oxidative stress and inflammation.
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