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Reactive Infectious Mucocutaneous Eruption (RIME): An Australian Case Series

Hamish Moore1,2, Emma Ryan1,3, Annabel Stevenson1,2,4

  • 1Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, South Australia, Australia.

The Australasian Journal of Dermatology
|February 16, 2026
PubMed

Insights

Reactive Infectious Mucocutaneous Eruption (RIME) causes significant illness and prolonged hospital stays in children. Early specialist diagnosis and awareness during Mycoplasma pneumoniae outbreaks are crucial for better outcomes.

Area of Science:

  • Pediatric Dermatology
  • Infectious Diseases
  • Epidemiology

Background:

  • Reactive Infectious Mucocutaneous Eruption (RIME) is a severe mucocutaneous condition.
  • RIME leads to substantial morbidity and healthcare resource utilization, including extended hospitalizations.

Purpose of the Study:

  • To analyze trends in etiology, diagnosis, management, and outcomes of pediatric RIME.
  • To emphasize the importance of early specialist intervention and awareness of triggers like Mycoplasma pneumoniae.

Main Methods:

  • Retrospective review of pediatric RIME cases in South Australia.
  • Data collection spanned from 2023 to 2024.

Main Results:

  • Identified key trends in RIME presentation and management.
  • Highlighted the association between RIME and Mycoplasma pneumoniae infections.

Conclusions:

  • Early pediatric dermatology consultation is vital for optimal RIME management.
  • Vigilance for RIME is necessary during Mycoplasma pneumoniae outbreaks.

Keywords:
Mycosplasma pneumoniaeMIRMRIMEetanerceptmucocutaneous eruptionreactive infectious mucocutaneous eruption

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