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Endocarditis II: Clinical Features of Infective Endocarditis

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Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...

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Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...

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The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...

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Updated: May 8, 2026

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Published on: December 15, 2011

Reactive Infectious Mucocutaneous Eruption (RIME): An Australian Case Series.

Hamish Moore^1,2, Emma Ryan^1,3, Annabel Stevenson^1,2,4

¹Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, South Australia, Australia.

The Australasian Journal of Dermatology

|February 16, 2026

Summary

Reactive Infectious Mucocutaneous Eruption (RIME) causes significant illness and prolonged hospital stays in children. Early specialist diagnosis and awareness during Mycoplasma pneumoniae outbreaks are crucial for better outcomes.

Keywords:

Mycosplasma pneumoniae MIRM RIME etanercept mucocutaneous eruption reactive infectious mucocutaneous eruption

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Published on: January 26, 2019

Area of Science:

Pediatric Dermatology
Infectious Diseases
Epidemiology

Background:

Reactive Infectious Mucocutaneous Eruption (RIME) is a severe mucocutaneous condition.
RIME leads to substantial morbidity and healthcare resource utilization, including extended hospitalizations.

Purpose of the Study:

To analyze trends in etiology, diagnosis, management, and outcomes of pediatric RIME.
To emphasize the importance of early specialist intervention and awareness of triggers like Mycoplasma pneumoniae.

Main Methods:

Retrospective review of pediatric RIME cases in South Australia.
Data collection spanned from 2023 to 2024.

Main Results:

Identified key trends in RIME presentation and management.
Highlighted the association between RIME and Mycoplasma pneumoniae infections.

Conclusions:

Early pediatric dermatology consultation is vital for optimal RIME management.
Vigilance for RIME is necessary during Mycoplasma pneumoniae outbreaks.