Feasibility Study of Modified Underwater Endoscopic Mucosal Resection for Colorectal Polyps

Area of Science:

• Gastroenterology
• Endoscopic Surgery
• Colorectal Cancer Screening

Background:

• Underwater endoscopic mucosal resection (UEMR) is standard for colorectal tumors but faces visualization challenges.
• Difficulties include dirty fluid, insufficient water, and bleeding, hindering clear endoscopic views.

Purpose of the Study:

• To investigate the safety and efficacy of a modified UEMR (M-UEMR) technique.
• M-UEMR involves underwater snaring followed by undergas resection.

Main Methods:

• A single-center prospective clinical trial enrolled patients with 10-25 mm colorectal polyps.
• The M-UEMR procedure involved underwater snaring, water removal, and CO2 insufflation for resection.
• Outcomes measured included R0 resection rate, adverse events, en bloc resection rate, and submucosal tissue thickness.

Main Results:

• The study enrolled 40 patients, achieving an 80% R0 resection rate.
• No procedure-related adverse events were observed.
• The en bloc resection rate was 92.5%.

Conclusions:

• Modified UEMR (M-UEMR) demonstrates a high R0 resection rate and a safe profile.
• M-UEMR is a promising alternative for colorectal polyps, especially when clear visualization is challenging.