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Durable Response to Glofitamab in HIV-Positive Refractory Burkitt Lymphoma: Case Report and Discussion

Bozzotto Elisa¹, Magnes Theresa¹, Kiem Dominik¹

¹Department of Internal Medicine III With Hematology, Medical Oncology, Hemostaseology, Infectiology, and Rheumatology Paracelsus Medical University University Clinic Salzburg Salzburg Austria.

|February 16, 2026

Abstract

Background:

Refractory Burkitt lymphoma (BL) has a dismal prognosis after failure of frontline therapy. New treatment options are urgently needed.

Methods:

We describe a 60-year-old HIV-positive patient with refractory and secondary primary BL after frontline and salvage therapy failure, treated off-label with glofitamab successfully.

Results:

Twelve cycles of glofitamab were well tolerated and led to complete metabolic remission confirmed by imaging and biopsy, sustained for nine months post-treatment.

Conclusion:

Glofitamab may represent a promising stand-alone option in relapsed BL, when conventional cytotoxic therapies are exhausted. Clinical Trial Registration: The authors have confirmed that clinical trial registration is not needed for this submission.

Keywords:

Burkitt lymphoma HIV bispecific antibodies glofitamab refractory lymphoma time‐limited therapy

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