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Methods to Investigate the Regulatory Role of Small RNAs and Ribosomal Occupancy of Plasmodium falciparum

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Case Report: IL2RA (CD25) deficiency: first reported cases in Morocco.

Ahamada Elamine¹, Ibtihal Benhsaien^1,2, Abderrahmane Errami¹

¹Laboratory of Clinical Immunology, Infection and Autoimmunity (LICIA), Faculty of Medicine and Pharmacy, Hassan II University, Casablanca, Morocco.

Frontiers in Immunology

|February 16, 2026

Summary

Interleukin-2 receptor alpha-chain (IL2RA) deficiency, marked by CD25 absence, causes severe autoimmunity and infections in infants. This study identifies two new Moroccan cases with distinct mutations, emphasizing early diagnosis for treatment.

Area of Science:

Immunology
Genetics
Pediatrics

Background:

CD25 (IL2RA) is crucial for regulatory T cell function.
Loss-of-function IL2RA variants cause rare IPEX-like disorders with autoimmunity and infections.

Keywords:

CD25 deficiency IL2RA deficiency IPEX-like syndrome Morocco autoimmunity immune dysregulation inborn errors of immunity regulatory T cells

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Previous cases of IL2RA deficiency have not been reported in Morocco.