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Oxycodone: A Pain-Relieving Agent With Cardioprotective Properties Against Myocardial Ischemia-Reperfusion Injury
Mehdi Dehghani Firoozabadi1, Behrang Nooralishahi1, Fatemeh Rezaei-Tazangi2
1Tehran Heart Center, Cardiovascular Diseases Research Institute, Anesthesiology, Critical Care and Pain Research Center, Tehran University of Medical Science, Tehran, Iran, tums.ac.ir.
Cardiovascular Therapeutics
|February 16, 2026
Summary
Oxycodone shows potential cardioprotective effects against myocardial ischemia-reperfusion injury (MIRI). It may mitigate MIRI by regulating apoptosis, inflammation, and oxidative stress, offering a promising therapeutic avenue.
Area of Science:
- Cardiovascular Diseases
- Pharmacology
Background:
- Myocardial ischemia-reperfusion injury (MIRI) is a critical cardiovascular condition with high mortality.
- Current treatments for MIRI have limitations in effectiveness.
- Oxycodone, an opioid analgesic, is emerging as a potential cardioprotective agent.
Purpose of the Study:
- To review and discuss the cardioprotective potential of oxycodone against MIRI.
- To elucidate the underlying mechanisms of oxycodone's anti-MIRI effects.
- To evaluate oxycodone's clinical applicability for MIRI patients.
Main Methods:
- This study is a narrative review.
- Literature search on oxycodone and MIRI was conducted.
- Experimental evidence on oxycodone's effects was summarized.
Main Results:
- Oxycodone demonstrates cardioprotective effects in experimental models of MIRI.
- These effects are attributed to the regulation of apoptosis, inflammation, and oxidative stress.
- Oxycodone improves infarct size, cardiac function, and endothelial integrity.
Conclusions:
- Oxycodone exhibits significant anti-MIRI potential.
- Its mechanisms involve modulating key cellular pathways.
- Further clinical assessment of oxycodone for MIRI is warranted.
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