Sustainable AGP alternatives: a systems approach to non-antibiotic growth regulators standardization, synergistic formulation and environmental safety
Contact us if these videos are not relevant.
Contact us if these videos are not relevant.
View abstract on PubMed
Summary
This summary is machine-generated.Consumer demand for antibiotic-free livestock is rising. This review explores non-antibiotic strategies like phytogenic food additives (PFAs) as sustainable alternatives to promote animal health and reduce antimicrobial resistance.
Area Of Science
- Animal Science
- Microbiology
- Food Safety
Background
- Growing consumer demand for antibiotic-free livestock products (RWA/NAE).
- Increasing antimicrobial resistance (AMR) crisis linked to antibiotic growth promoters (AGPs).
- Stringent regulatory restrictions on in-feed antibiotics necessitate sustainable alternatives.
Purpose Of The Study
- To review and evaluate non-antibiotic strategies for enhancing livestock production.
- To establish a benchmark for alternative efficacy based on AGP mechanisms (gut microbiota, immunomodulation).
- To identify preferred alternatives aligning with global bans on in-feed antibiotics.
Main Methods
- Critical evaluation of current antibiotic substitutes: probiotics, prebiotics, synbiotics, organic acids, enzymes, and phytogenic food additives (PFAs).
- Assessment of emerging technologies: antimicrobial peptides (AMPs), IgY, bacteriophages, genomic medicines, clays, and trace minerals.
- Highlighting commercially approved examples, e.g., bacteriophages for Salmonella control.
Main Results
- Phytogenic food additives (PFAs) are identified as preferred alternatives due to antimicrobial, antioxidant, and gut health properties, alongside cost-efficiency and scalability.
- Demonstrated success of alternatives in improving feed efficiency, growth performance, and animal health.
- Challenges remain regarding consistency, bioavailability, and regulatory approval for many alternatives.
Conclusions
- A strategic combination of natural and advanced alternatives, especially optimized PFA formulations, offers a viable path to antibiotic-free animal husbandry.
- These alternatives are crucial for mitigating AMR risks and ensuring future food security.
- Further research and development are needed to overcome existing challenges and facilitate widespread adoption.
Contact us if these videos are not relevant.
Contact us if these videos are not relevant.
Related Concept Videos
Biological agents offer an effective means of controlling microbial growth by leveraging natural processes like predation, competition, and the secretion of antimicrobial substances.Predatory bacteria such as Bdellovibrio species target and kill pathogens like Salmonella and E. coli. They are widely used in poultry farms to control infections. Myxococcus species help combat plant-pathogenic fungi. These naturally occurring predators serve as eco-friendly alternatives to chemical pesticides and...
Microbial growth control refers to various methods employed to inhibit, reduce, or eliminate microorganisms to ensure safety and hygiene across different settings. These methods are categorized based on the target environment and the level of microbial control required.Biocides are versatile agents designed to control microorganisms by either inhibiting their growth or outright killing them. These agents work through various physical, chemical, mechanical, or biological mechanisms. The...
Global regulatory systems in bacteria enable rapid and coordinated responses to environmental changes by integrating sensory inputs with gene expression, ensuring efficient adaptation to fluctuating conditions. Key global regulatory mechanisms include regulons, two-component systems, sigma factors, and secondary messengers.Regulons and Global RegulatorsA regulon is a collection of genes and operons controlled by a common global regulator. These regulators enable bacteria to prioritize resource...
Generic intravenous (IV) drugs are considered bioequivalent to their branded counterparts due to their 100% bioavailability upon administration. However, variations in stability among different drug products can significantly influence their therapeutic performance, even if they are pharmaceutically equivalent.Cefuroxime, a prophylactic antimicrobial, is often used as a single-dose IV injection for patients undergoing coronary artery bypass grafting surgery. A 3 g dose typically provides...
Overview
Researchers use antibiotic resistance genes to identify bacteria that possess a plasmid containing their gene of interest. Antibiotic resistance naturally occurs when a spontaneous DNA mutation creates changes in bacterial genes that eliminate antibiotic activity. Bacteria can share these new resistance genes with their offspring and other bacteria. The overuse and misuse of antibiotics have created a public health crisis, as resistant and multi-resistant bacteria continue to develop.
Quorum sensing is a mechanism of bacterial communication that enables coordinated gene expression in response to changes in population density. This facilitates collective behaviors that enhance survival, resource acquisition, and ecological adaptation. This process relies on small signaling molecules called autoinducers that accumulate as bacterial populations grow. When a critical threshold concentration of autoinducers is reached, bacterial cells collectively modify gene expression,...