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Acromegaly-induced dilated cardiomyopathy presenting with heart failure as the cardinal symptom: A case report
Jiamin Xu1, Jie Liu1, Heng Wu1
1Cardiovascular Disease Center, The Central Hospital of Enshi Tujia and Miao Autonomous Prefecture, Enshi Clinical College of Wuhan University, China.
Insights
Acromegaly, a growth hormone disorder, can cause heart failure due to acromegalic cardiomyopathy. This case report details a pituitary adenoma leading to this serious condition.
Area of Science:
- Endocrinology
- Cardiology
- Oncology
Background:
- Acromegaly is a rare endocrine disorder caused by excess growth hormone (GH) and elevated insulin-like growth factor-1 (IGF-1).
- It significantly increases the risk of cardiovascular complications, including cardiomyopathy, arrhythmias, and heart failure.
- Acromegalic cardiomyopathy is the leading cause of mortality in affected patients.
Abstract:
Acromegaly is a rare endocrine disorder caused by excessive secretion of growth hormone, resulting in elevated serum levels of hepatic insulin-like growth factor-1 (IGF-1). With an estimated annual incidence of approximately three cases per million individuals, the condition is associated with a significantly increased risk of cardiovascular complications, such as arrhythmias and acromegaly-induced cardiomyopathy. Heart failure secondary to acromegalic cardiomyopathy occurs in approximately 3% of affected patients and is recognized as the leading cause of mortality in individuals with this condition. This case report describes a 53-year-old male diagnosed with acromegalic cardiomyopathy caused by a pituitary adenoma.
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