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Updated: Feb 17, 2026
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Preparation of Binary and Ternary Deep Eutectic Systems
Published on: October 31, 2019
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Monoterpenoid-Based Deep Eutectic Solvents/Natural Deep Eutectic Solvents: A Review on Its Characteristics and
Felipe Gois Mota1, Evertan Antonio Rebelatto1, Laís Benvenutti1
1Department of Chemical and Food Engineering, Technological Center, Federal University of Santa Catarina, 88040900 Florianópolis, Brazil.
ACS Omega
|February 16, 2026
Summary
Deep eutectic solvents (DES) and natural deep eutectic solvents (NADES) show promise as green extraction solvents. Monoterpenoid-based NADES are particularly effective for extracting bioactive compounds from food matrices.
Area of Science:
- Green Chemistry
- Solvent Technology
- Sustainable Extraction
Background:
- Deep eutectic solvents (DES) and natural deep eutectic solvents (NADES) are emerging as environmentally friendly alternatives to traditional solvents.
- Their application in extraction processes is gaining traction due to their tunable properties and low toxicity.
- Monoterpenoids, as components of NADES, offer unique characteristics for specific extraction needs.
Purpose of the Study:
- To review recent literature (2020-2025) on DES and NADES derived from monoterpenoids for extraction.
- To explore their production methods and diverse applications, including biorefinery and integration with supercritical CO2.
- To highlight their potential in extracting valuable compounds from various matrices.
Main Methods:
- Literature review of studies focusing on monoterpenoid-based DES/NADES.
- Analysis of extraction processes utilizing these green solvents, often combined with advanced techniques.
- Examination of solvent preparation methods using different energy sources.
Main Results:
- Monoterpenoid-based DES/NADES demonstrate significant potential for extracting bioactive compounds, antioxidants, and natural pigments.
- Combining these green solvents with methods like ohmic heating, ultrasound, microwave, and supercritical technology enhances extraction efficiency.
- Successful preparation of DES/NADES is achievable using conventional heating, microwave, or ultrasound.
Conclusions:
- Monoterpenoid-based DES/NADES are highly suitable for industrial extraction, especially for bioactive compounds in food.
- These sustainable solvents offer broad application potential across health, pharmacy, chemistry, and environmental sectors.
- Further research into their combination with supercritical CO2 and thermophysical properties is recommended for technological advancement.
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