CFD Mechanistic Modeling of a Monolithic Chromatography System: Challenges and Opportunities

Monolithic chromatographic supports are part of the fourth generation of chromatographic separation media. A comprehensive knowledge of the transport phenomena described by mechanistic models is important for the purposes of project design for meeting regulatory requirements and optimizing production. Although geometric characteristics influence monolithic support properties, few approaches have incorporated morphology details into the models. Thus, there is a gap for new model developments in complex porous matrices, which may be alternatives to the more classic phenomenological approaches. This review differs from those previously published by demonstrating the utilization of computer-aided engineering to enhance the construction and modification of channel microstructures for the purpose of achieving more effective separation, integrating mathematical models, and constructing porous geometries. This work presents the status quo evolution of mathematical models and also presents the trends, challenges, and opportunities.