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Updated: Feb 17, 2026

Directed Assembly of Elastin-like Proteins into defined Supramolecular Structures and Cargo Encapsulation In Vitro
Published on: April 8, 2020
A new class of customisable stable boronic ester assemblies
D Coomber1, O Rusli2, H Sharma1
1School of Life and Environmental Sciences, Centre for Sustainable Bioproducts, Deakin University Waurn Ponds VIC 3216 Australia fred.pfeffer@deakin.edu.au.
Abstract:
An efficient, customisable approach for the assembly of covalent macrocycles and cages has been developed using the reaction of fused polynorbornane based bis-diols and commercially available boronic acids. The ability to customise the requisite bis-diol to various lengths and dihedral angles (here both 90° and 180°) and then combine with di or triboronic acids allows access to range of architectures. The resultant constructs were resistant to hydrolysis including 24-hour exposure to dilute solutions of either acetic or trifluoroacetic acid.
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