Related Experiment Video
Updated: Feb 17, 2026

Rapid Screening of HIV Reverse Transcriptase and Integrase Inhibitors
Published on: April 9, 2014
Late-Onset Efavirenz-Induced Liver Toxicity in a 17-Year-Old, Filipino, Patient With HIV
John Derek C Clutario1, Sharlene Nicole L Chan1, Gerardo S Pedregosa1
1Makati Medical Center, Makati City, Philippines.
Abstract:
Efavirenz is a non-nucleoside reverse transcriptase inhibitor widely used in HIV treatment. Although generally well-tolerated, rare cases of severe hepatotoxicity have been reported. We present a case of a patient on efavirenz-based highly active antiretroviral therapy who developed jaundice and marked transaminitis 1 year after initiation. Infectious, autoimmune, and toxic causes were ruled out, and genetic testing revealed no metabolic abnormalities. Treatment involved corticosteroids, immunosuppressants, and switching to dolutegravir, leading to resolution. This is the first documented case in the Philippines of delayed-onset efavirenz-induced liver injury, underscoring the importance of ongoing liver monitoring during antiretroviral therapy.
More Related Videos
Related Concept Videos
Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment
Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test
Hepatic Drug Excretion: Influencing Factors
Drug Toxicity: Risk factors
Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow
Pharmacokinetics: Drug–Food and Drug–Viral Interactions

