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Management of Thyroid Eye Disease: A Comparison Between Three Recent Clinical Guidelines
Chaoyu Lei1,2, Jun Jin1, Runchuan Li1
1State Key Laboratory of Eye Health, Department of Ophthalmology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Ophthalmology and Therapy
|February 16, 2026
Summary
Three new thyroid eye disease (TED) guidelines offer consensus but differ in management. This review compares these guidelines to inform future patient care strategies for TED.
Area of Science:
- Ophthalmology
- Endocrinology
- Thyroidology
Background:
- Recent advancements in thyroid eye disease (TED) diagnosis and treatment.
- Development of three distinct patient care guidelines by major regional professional societies.
Purpose of the Study:
- To compare and contrast recommendations from three major thyroid eye disease guidelines.
- To identify variations in diagnostic and treatment strategies across guidelines.
- To explore potential reasons for discrepancies and suggest future directions in TED management.
Main Methods:
- Comparative analysis of guidelines from the European Group on Graves' Orbitopathy, Chinese Medical Association, and American Thyroid Association/European Thyroid Association.
- Evaluation across 11 key dimensions, including diagnosis and treatment.
- Exploration of the root causes of identified variations.
Main Results:
- Broad consensus exists across the three guidelines for thyroid eye disease management.
- Significant differences in recommendations were identified, potentially impacting patient care.
- Variations span from initial diagnosis to advanced treatment strategies.
Conclusions:
- Understanding guideline variations is crucial for consistent thyroid eye disease patient management.
- Further research is needed to reconcile differences and establish optimal global treatment protocols.
- The review provides a comprehensive perspective on current and future TED management.
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