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Updated: Feb 18, 2026

A Flow Cytometry-Based Cell Surface Protein Binding Assay for Assessing Selectivity and Specificity of an Anticancer Aptamer
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A Flow Cytometry-Based Cell Surface Protein Binding Assay for Assessing Selectivity and Specificity of an Anticancer Aptamer

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Aptamers-based drug: A new paradigm for precise treatment

Yuwen Zhou1, Shiqin Hong2, Xiaojie Xu3

  • 1State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine/School of Pharmaceutical Sciences, Guizhou Medical University, Guiyang, 561113, China; College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China.

European Journal of Medicinal Chemistry
|February 16, 2026
PubMed
Summary

Aptamer-drug conjugates (ApDCs) offer advanced precision delivery for cancer therapy, surpassing antibody-drug conjugates (ADCs). This review highlights recent progress and strategies to overcome challenges in ApDC development and clinical use.

Keywords:
AptamerAptamer-drug conjugate (ApDC)Drug deliveryPrecision medicineSELEXTargeted therapy

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