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Cerebro-cerebellar structure-function coupling's role in motor recovery after infarction
Jing Liu1, Yi Shan1, Bi-Xiao Cui1
1Department of Radiology and Nuclear Medicine, Xuanwu Hospital, Capital Medical University, 45 Changchun Street, Xicheng District, Beijing 100053, China; Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, Beijing, China.
Neuroimage
|February 16, 2026
Summary
Focal subcortical infarction impacts motor pathways, revealing cerebro-cerebellar circuit structure-function coupling. The dorsal spinocerebellar tract (DSCT) is key for predicting lower limb recovery after stroke.
Area of Science:
- Neuroscience
- Neurology
- Medical Imaging
Background:
- Subcortical infarction can lead to motor impairments.
- Understanding structure-function relationships is crucial for predicting recovery.
Purpose of the Study:
- To investigate pathway-specific structure-function coupling after subcortical infarction.
- To determine the influence of this coupling on clinical motor symptoms.
Main Methods:
- Prospective study of 50 patients with subcortical infarction and 50 controls.
- Utilized resting-state fMRI, DTI, and Fugl-Meyer-Assessment (FMA-LE) at multiple time points.
- Analyzed structural integrity of key motor tracts (CST, DTCT, CPCT, DSCT) and their functional connectivity (FC).
Main Results:
- Patients showed reduced structural integrity in DTCT, DSCT, and CST compared to controls.
- Identified structure-function couplings within the cerebro-cerebellar circuit involving DTCT, DSCT, and CST.
- Baseline DSCT structural integrity influenced the relationship between FC and motor function recovery over 30 days.
Conclusions:
- Cerebro-cerebellar circuit structure-function coupling is a significant finding post-infarction.
- The dorsal spinocerebellar tract (DSCT) pathway is a critical mediator for prognosis.
- This coupling serves as a biomarker for lower limb recovery and guides rehabilitation strategies.
Keywords:
Cerebral infarctionCerebro-cerebellarDiffusion tensor imagingMotor recoveryResting-state fMRIMore Related Videos
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