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Gut microbiome profile among children and adolescents living with sickle cell disease: a protocol for systematic

Abideen Olurotimi Salako1, Joseph Ikeh Ogbeh2, Hafeez Aderinsayo Adekola3

  • 1Clinical Sciences Department, Nigerian Institute of Medical Research, Lagos, Nigeria.

BMJ Open
|February 16, 2026
PubMed

Insights

This review examines the gut microbiome in children with sickle cell disease (SCD), exploring how medications and environment impact gut bacteria. Findings will guide microbiome-targeted strategies for better pediatric SCD care.

Area of Science:

  • Microbiology
  • Pediatric Hematology
  • Gastroenterology

Background:

  • Sickle cell disease (SCD) significantly impacts children's health.
  • The gut microbiome's role in SCD is increasingly recognized.
  • Understanding gut microbiota in pediatric SCD is crucial for targeted interventions.

Purpose of the Study:

  • To synthesize evidence on gut microbiome profiles in pediatric SCD.
  • To assess the impact of analgesics and antibiotics on gut microbiota diversity.
  • To explore environmental factors influencing gut microbiota in SCD.

Main Methods:

  • Systematic review of studies on pediatric SCD gut microbiota.
  • Comprehensive literature search across major databases (PubMed, Scopus, etc.).
  • Data extraction and evidence strength assessment using GRADE criteria.

Main Results:

  • Consistent microbial patterns in pediatric SCD are yet to be fully elucidated.
  • Gaps in current research highlight the need for further investigation.
  • Potential influence of medications and environmental factors requires detailed analysis.

Conclusions:

  • Further research into the pediatric SCD gut microbiome is warranted.
  • Microbiome-targeted strategies may offer novel therapeutic avenues.
  • This review provides insights for improving health outcomes in pediatric SCD care.
Abstract

Keywords:
AdolescentsGASTROENTEROLOGYPUBLIC HEALTHPaediatric gastroenterologySystematic Review

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