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Updated: Feb 18, 2026

Orthotopic Ovarian Transplantation Procedures to Investigate the Life- and Health-span Influence of Ovarian Senescence in Female Mice
Published on: February 12, 2018
Pregnancy lab test dynamics resemble rejuvenation of some organs and aging of others
Ron Moran1, Glen Pridham1, Yoel Toledano2
1Dept. Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.
Abstract:
Pregnancy and aging are associated with stress on the body and show multi-system physiological changes. We asked whether we can learn about aging from the changes in pregnancy. To do so, we analyzed weekly cross-sectional data on 70 lab tests from 300,000 pregnancies and 1.4 million non-pregnant females aged 20-89. Using a biological age model trained on non-pregnant females, we observed that pregnant females' apparent age dropped by 5 years in the first trimester, rose by 20 years toward delivery, and recovered postpartum. Pregnancy complications increased apparent age by 2-6 years. Certain systems exhibited apparent rejuvenation - opposite trends in pregnancy vs aging - including renal, iron, and most liver tests. Others, such as coagulation, thyroid, muscle, and metabolism, showed apparent aging. Notably, the aging-like mechanisms of pregnancy differed from normal aging, suggesting superficial similarity, whereas the rejuvenation-like mechanisms may offer clues for slowing aspects of biological aging.
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