Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Glial Cells01:04

Glial Cells

94.9K
Overview
94.9K
Nervous Tissue: Glial Cells01:31

Nervous Tissue: Glial Cells

7.1K
Glia, or neuroglia, are vital support cells that assist neurons in their functions. The term "glia" originates from the Greek word for "glue," reflecting their role in holding the nervous system together. These cells can be categorized into six types: four in the central nervous system (CNS) and two in the peripheral nervous system (PNS).
The CNS glial cell includes the astrocytes, the oligodendrocytes, the microglia, and the ependymal cells.
Astrocytes are star-shaped glial...
7.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A dynamic reward framework for scalable and efficient IoT-WSN routing using deep reinforcement learning.

Scientific reports·2026
Same author

Genomic and phenotypic insights into the probiotic and antimicrobial potential of Bacillus amyloliquefaciens BCSIR-AJ strain from garlic chutney.

Archives of microbiology·2026
Same author

Human embryonic stem cell-derived dopaminergic cells for Parkinson's disease: a phase 1/2 open-label trial.

Nature medicine·2026
Same author

Geochemistry and radiation risk of radium isotopes and heavy metal contamination in groundwater of Dhaka City, Bangladesh.

Environmental science. Processes & impacts·2026
Same author

Genomic and phenotypic characterization of non-O157 Shiga toxin-producing <i>Escherichia coli</i> from Bangladeshi cattle reveals diverse virulence and resistance profiles.

Microbiology spectrum·2026
Same author

Draft genome sequence of an alkaliphilic drug-resistant <i>Burkholderia cenocepacia_DG4</i> strain isolated from commercial liquid detergent in Bangladesh.

Microbiology resource announcements·2026

Related Experiment Video

Updated: Feb 18, 2026

Primary Culture of Mouse Dopaminergic Neurons
11:58

Primary Culture of Mouse Dopaminergic Neurons

Published on: September 8, 2014

39.4K

Distinct radial glia subtypes regulate midbrain dopaminergic neuron development.

Emilía Sif Ásgrímsdóttir1, Luca Fusar Bassini2, Ting Sun3

  • 1Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden. emiliasifa@gmail.com.

Nature Neuroscience
|February 16, 2026
PubMed
Summary
This summary is machine-generated.

Researchers identified distinct radial glia (Rgl) subtypes in the developing midbrain. Rgl1 generates dopaminergic neurons, regulated by BMAL1, while Rgl3 factors enhance human stem cell-derived neuron yield for Parkinson's disease therapies.

More Related Videos

Lineage Tracing and Clonal Analysis in Developing Cerebral Cortex Using Mosaic Analysis with Double Markers MADM
09:25

Lineage Tracing and Clonal Analysis in Developing Cerebral Cortex Using Mosaic Analysis with Double Markers MADM

Published on: May 8, 2020

11.3K
Derivation of Glial Restricted Precursors from E13 mice
08:56

Derivation of Glial Restricted Precursors from E13 mice

Published on: June 20, 2012

11.7K

Related Experiment Videos

Last Updated: Feb 18, 2026

Primary Culture of Mouse Dopaminergic Neurons
11:58

Primary Culture of Mouse Dopaminergic Neurons

Published on: September 8, 2014

39.4K
Lineage Tracing and Clonal Analysis in Developing Cerebral Cortex Using Mosaic Analysis with Double Markers MADM
09:25

Lineage Tracing and Clonal Analysis in Developing Cerebral Cortex Using Mosaic Analysis with Double Markers MADM

Published on: May 8, 2020

11.3K
Derivation of Glial Restricted Precursors from E13 mice
08:56

Derivation of Glial Restricted Precursors from E13 mice

Published on: June 20, 2012

11.7K

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Stem Cell Biology

Background:

  • Midbrain dopaminergic (mesDA) neurons are crucial for motor control and Parkinson's disease (PD) therapies.
  • Radial glia (Rgl) cells in the ventral midbrain (VM) are the primary progenitors of mesDA neurons.
  • The specific roles of distinct Rgl subtypes in mesDA neurogenesis remain largely undefined.

Purpose of the Study:

  • To delineate the distinct contributions of Rgl subtypes to mesDA neuron development.
  • To identify key regulators of mesDA neurogenesis within Rgl populations.
  • To uncover factors that can improve the generation of human stem cell-derived mesDA neurons for therapeutic applications.

Main Methods:

  • Transcriptomic analysis of mouse and human VM Rgl populations.
  • Identification and validation of key transcriptional regulators (e.g., BMAL1).
  • Assessment of signaling factors from Rgl subtypes on human stem cell differentiation.

Main Results:

  • Rgl1 identified as the specific progenitor of the mesDA lineage.
  • A BMAL1-coordinated transcriptional network in Rgl1 regulates mesDA neurogenesis.
  • Rgl3 identified as a signaling subtype; its factors enhance survival and yield of human stem cell-derived mesDA neurons.

Conclusions:

  • Distinct Rgl subtypes (Rgl1 and Rgl3) play specific, non-redundant roles in VM development.
  • BMAL1 is a novel regulator of mesDA neurogenesis.
  • Rgl3-derived factors represent promising targets for improving clinical-grade mesDA neuron generation for PD cell replacement therapy.