Xanthelasma-Like Reaction Following Poly-L-Lactic Acid Intradermal Injection Managed With Fractional Non-Ablative...

Area of Science:

• Dermatology
• Aesthetic Medicine
• Regenerative Medicine

Background:

• Xanthelasma-like periocular plaques are rare adverse reactions to injectable collagen stimulators.
• These lesions present cosmetic challenges in sensitive facial areas.
• Management of such reactions can be difficult.

Purpose of the Study:

• To document a rare xanthelasma-like reaction post-polymer-based collagen stimulator injection.
• To evaluate the efficacy of fractional non-ablative lasers and stem cell-derived conditioned media in managing these lesions.

Main Methods:

• A case study of a 49-year-old woman with Fitzpatrick skin type IV presenting with bilateral infraorbital plaques.
• Initial treatment involved fractional 1550-nm erbium glass laser with intralesional sodium chloride and oral corticosteroids.
• Subsequent treatment combined fractional 1550-nm erbium glass and 1450-nm diode lasers, followed by intradermal stem cell-derived conditioned media.

Main Results:

• Partial improvement was noted after the initial treatment phase.
• Combination laser therapy with stem cell-derived conditioned media led to further significant lesion flattening and reduced erythema.
• Sustained improvement was observed at a four-month follow-up.

Conclusions:

• This case highlights a rare xanthelasma-like reaction to polymer-based collagen stimulators.
• A staged, non-ablative fractional laser approach combined with stem cell-derived conditioned media offers an effective and minimally invasive management strategy.
• This treatment combination shows promise for managing challenging periocular lesions.