Association of systemic inflammatory response index with severity of preeclampsia

The systemic inflammatory response index (SIRI), a novel and integrated hematological index calculated as (neutrophil count × monocyte count)/lymphocyte count, has been recognized as a reliable marker of systemic inflammation. This article undertakes an analysis of clinical data from preeclampsia (PE) patients, aiming to comprehensively assess the relationship between SIRI, PE, and the severity of PE.

A total of 783 pregnant women in their third trimester were divided into severe preeclampsia (SP) (n = 275), non-SP (n = 273), and control (n = 235) groups. Pearson correlation analysis was performed to investigate the relationship between SIRI and blood pressure. Receiver operating characteristic (ROC) curves were employed to evaluate the predictive ability of SIRI. Multivariate logistic regression analysis was used to assess the association between SIRI and the severity of PE.

There was a significant relationship between SIRI and systolic blood pressure (r = 0.488, p < 0.001) as well as diastolic blood pressure (r = 0.462, p < 0.001). ROC curve revealed that pregnant women with SIRI ≥ 1.84 × 10⁹/L were more likely to experience non-SP (AUC: 0.662; 95% CI: 0.615-0.710; p < 0.001), and those with SIRI ≥ 2.45 × 10⁹/L were prone to SP (AUC: 0.879; 95% CI: 0.850-0.910; p < 0.001). Multivariate logistic regression analysis demonstrated that SIRI served as an independent risk factor for both non-SP and SP (p < 0.001).

There is a strong correlation between SIRI and the severity of PE, and SIRI shows potential in predicting the severity of PE.