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Related Concept Videos

Bone Disorders01:29

Bone Disorders

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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
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Osteoclasts in Bone Remodeling01:31

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Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
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Combination Therapies and Personalized Medicine02:50

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Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
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Bone Remodeling01:40

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Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
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Urinary Tract Calculi IV: Nutrition Therapy and Prevention01:27

Urinary Tract Calculi IV: Nutrition Therapy and Prevention

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Management of renal calculi focuses on effective strategies like tailored nutrition and hydration therapy. Adjusting diet and fluid intake reduces stone formation and recurrence, making these interventions simple yet powerful in kidney stone prevention and management.Understanding Kidney StonesKidney stones form when calcium, oxalate, uric acid, and cystine concentrate and crystallize in urine. Factors contributing to their formation include genetic predisposition, certain medical conditions,...
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Role of Vitamins in Maintaining Bone Health01:25

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The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
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Updated: Feb 18, 2026

Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model
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Osteoporosis Update: Personalized Risk Assessment and Treatment.

Nayoung Sung1, Rachel Novik1, Madeline Cohn1

  • 1Obstetrics and Gynecology Institute, Cleveland Clinic, Cleveland, Ohio, USA.

Journal of Women'S Health (2002)
|February 17, 2026
PubMed
Summary
This summary is machine-generated.

This clinical update summarizes recent osteoporosis research, focusing on diagnosis and management. Key findings include guidelines on trabecular bone score (TBS) and treatment, plus insights into romosozumab

Keywords:
anabolicantiresorptivebone densityfractureosteoporosistrabecular bone score

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Area of Science:

  • Osteoporosis diagnosis and management
  • Clinical practice guidelines
  • Pharmacological treatments

Background:

  • Recent high-impact studies may influence osteoporosis clinical practice.
  • Current clinical practice needs updates on osteoporosis diagnosis and management.
  • Emerging data necessitates a review of osteoporosis treatment strategies.

Purpose of the Study:

  • To provide a concise overview of recent, high-impact journal articles on osteoporosis.
  • To review international guidelines on trabecular bone score (TBS) and goal-oriented treatment.
  • To discuss emerging data on romosozumab's cardiovascular safety and zoledronate utilization.

Main Methods:

  • Literature review of recently published, high-impact journal articles.
  • Synthesis of international guidelines on trabecular bone score (TBS) and treatment.
  • Analysis of emerging data on drug safety and treatment underuse.

Main Results:

  • Highlights essential guidelines on the clinical use of trabecular bone score (TBS).
  • Reviews a goal-oriented approach to osteoporosis treatment.
  • Presents emerging data on romosozumab's cardiovascular safety.
  • Underscores the underuse of zoledronate, particularly in early postmenopausal women and older adults post-hip fracture.

Conclusions:

  • Recent studies offer valuable insights for optimizing osteoporosis diagnosis and management.
  • Adherence to updated guidelines on TBS and treatment approaches is crucial.
  • Further investigation into romosozumab's cardiovascular effects and improved zoledronate utilization are warranted.