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Related Concept Videos

Radiological Investigation III: Pulmonary Angiogram and PET Scan01:13

Radiological Investigation III: Pulmonary Angiogram and PET Scan

Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
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Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
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Related Experiment Video

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Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
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In-Silico Trial of Same-Day Simulation-Free Spatially Fractionated Adaptive Radiotherapy (SF2-ART).

Dennis N Stanley1, Alyssa R Birchmeier1, Carlos E Cardenas1

  • 1Department of Radiation Oncology, University of Alabama at Birmingham, Birmingham, Alabama, USA.

Journal of Applied Clinical Medical Physics
|February 17, 2026
PubMed
Summary
This summary is machine-generated.

This study shows a new same-day, simulation-free radiotherapy workflow is feasible. Spatially fractionated adaptive radiotherapy (SF2-ART) can be delivered quickly without CT simulation, maintaining treatment quality.

Keywords:
CT Guided Adaptive RT (CTgART)Online Adaptive RTSimulation FreeSpatially FractionatedVirtual Clinical Study

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Area of Science:

  • Radiation oncology
  • Medical physics
  • Computational biology

Background:

  • Spatially fractionated radiotherapy (SFRT) offers dose escalation benefits.
  • Adaptive radiotherapy (ART) improves treatment accuracy by adjusting to anatomical changes.
  • Integrating these techniques into a streamlined workflow is challenging.

Purpose of the Study:

  • To evaluate the feasibility and deliverability of a same-day, simulation-free workflow for Spatially Fractionated Adaptive Radiotherapy (SF2-ART).
  • To assess the Varian Ethos platform's capability for this novel workflow.
  • To determine if CT simulation can be eliminated for SF2-ART.

Main Methods:

  • An in-silico trial involving 10 patients (5 thoracic, 5 extremity) previously treated with SFRT.
  • A two-phase simulated regimen including SBRT and GTV boost.
  • Simulation-free planning using custom scripts for high-dose matrices and CBCT-based adaptation.

Main Results:

  • All 10 cases were successfully replanned using the SF2-ART workflow without simulation CT.
  • The entire planning and treatment process was completed within a single session.
  • Dosimetric quality was maintained with minimal differences compared to original plans; median workflow time was 166.4 min.

Conclusions:

  • Same-day, simulation-free SF2-ART is feasible using the Varian Ethos platform.
  • This workflow enables rapid, high-quality treatment for urgent patient presentations.
  • Supports prospective clinical trials for SF2-ART implementation.