Related Experiment Video
Updated: Feb 18, 2026
06:01
A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
Published on: August 18, 2015
15.6K
Circadian Variability in Pediatric Arterial Ischemic Stroke
Sarah Lee1, Anirudh Sreekrishnan2, Michael Mlynash1
1Stanford Stroke Center, Department of Neurology & Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.
The Journal of Pediatrics
|February 17, 2026
Summary
Pediatric ischemic stroke shows circadian variability, with most events occurring in the afternoon. Nighttime strokes were linked to arteriopathy risk factors, suggesting different underlying causes and potential treatment implications.
Area of Science:
- Neurology
- Pediatrics
- Circadian Biology
Background:
- Ischemic stroke is a significant cause of childhood morbidity.
- Understanding the temporal patterns of stroke onset is crucial for developing effective prevention and treatment strategies.
Purpose of the Study:
- To investigate whether the timing of ischemic stroke onset exhibits circadian variability in pediatric patients.
- To explore potential differences in stroke characteristics and outcomes based on the time of day.
Main Methods:
- A retrospective cohort study was conducted using data from a large, multicenter pediatric stroke registry.
- Children with arterial ischemic stroke and known onset times were analyzed.
- Stroke onset times were categorized into four epochs: morning, afternoon, evening, and night.
- Statistical tests (Kruskal-Wallis, chi-square) were used for comparisons.
Main Results:
- A total of 478 children were included, with a mean age of 9.9 years.
- The highest frequency of strokes occurred in the afternoon (38.7%), followed by the morning (32.6%).
- Arteriopathy risk factors were more common in nighttime strokes (P = .034).
- Younger age groups (<11 years) showed a higher proportion of afternoon strokes.
Conclusions:
- Circadian patterns of ischemic stroke in children appear distinct from those observed in adults.
- These findings highlight the need for tailored stroke care systems and treatment approaches for pediatric populations.
- Further research may elucidate the specific mechanisms driving these temporal variations.
Related Concept Videos
01:15Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response
394
Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
394
01:27Regulation of Stroke Volume
5.3K
The regulation of stroke volume, which is the amount of blood the heart pumps out during each heartbeat, is critical for maintaining a healthy circulatory system. Stroke volume is influenced by three main factors: preload, contractility, and afterload.
Preload refers to the degree of stretch on the heart before it contracts. It's analogous to the stretching of a rubber band; the more it's stretched, the more forcefully it snaps back. This concept is encapsulated in the Frank-Starling law of the...
Preload refers to the degree of stretch on the heart before it contracts. It's analogous to the stretching of a rubber band; the more it's stretched, the more forcefully it snaps back. This concept is encapsulated in the Frank-Starling law of the...
5.3K
01:24Pharmacokinetics in Pediatric Patients: Drug Metabolism
257
In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
257
01:17Pharmacokinetics in Pediatric Patients: Drug Distribution
337
Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight,...
337