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Short- and Long-Term Prognosis of COVID-19-Associated Versus Non-COVID-19 Takotsubo Cardiomyopathy: A

Didien Meyahnwi1, Yussif Issaka1, Efeturi M Okorigba2

  • 1Department of Medicine, Yale New Haven Health Bridgeport Hospital, Bridgeport, USA.

Cureus
|February 17, 2026
PubMed

Insights

Coronavirus disease 2019 (COVID-19) associated Takotsubo cardiomyopathy (TCM) does not increase short-term mortality. However, COVID-19 TCM patients face higher risks of acute complications and worse one-year survival.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Public Health

Background:

  • Takotsubo cardiomyopathy (TCM) is a stress-induced heart condition.
  • Coronavirus disease 2019 (COVID-19) can trigger TCM, but outcomes data are limited.
  • Previous studies focused on early pandemic data when treatments were scarce.

Purpose of the Study:

  • To compare outcomes for COVID-19-related TCM versus non-COVID-19 TCM.
  • To assess short-term and long-term mortality and complications.
  • To understand the persistent impact of COVID-19 on heart health.

Main Methods:

  • Retrospective cohort study using the TriNetX database (March 2020-March 2025).
  • Identified US adults hospitalized with TCM, comparing COVID-19 positive vs. negative cohorts.
  • Propensity score matching used to balance cohorts; analyzed 30-day and one-year mortality and complications.

Main Results:

  • No significant difference in 30-day mortality between COVID-19 TCM and non-COVID-19 TCM groups (12.0% vs. 11.1%).
  • COVID-19 TCM associated with increased risks of heart failure with reduced ejection fraction, cardiogenic shock, and ventricular arrhythmias.
  • One-year mortality was significantly higher in the COVID-19 TCM cohort (22.0% vs. 18.3%).

Conclusions:

  • COVID-19-associated TCM does not increase immediate mortality risk.
  • COVID-19 TCM patients have higher risks of acute cardiac complications.
  • Long-term survival is significantly worse for individuals with COVID-19-associated TCM, indicating lasting effects.
Abstract

Keywords:
acute systolic heart failurecardiac complicationscovid-19heart failure with reduced ejection fractionlong-covid-19sars-cov-2 infectionstress induced cardiomyopathytakotsubo cardiomyopathy

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