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Peak expiratory flow causally affects brain neuronal activity: A Mendelian randomization study.

Yumeng Mao1,2, Jing Xu3, Dafa Shi1,2

  • 1Department of Radiology, The Second Affiliated Hospital of Xiamen Medical College, Xiamen, Fujian, China.

Technology and Health Care : Official Journal of the European Society for Engineering and Medicine
|February 17, 2026
PubMed
Summary

This study reveals that reduced peak expiratory flow (PEF) causally impacts brain neuronal activity. Monitoring PEF in lung disease patients may help detect early brain function changes.

Keywords:
Mendelian randomizationbrain neuronal activitycausalitylung functionpeak expiratory flow

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Area of Science:

  • Neuroscience
  • Pulmonology
  • Genetics

Background:

  • The lung-brain axis suggests cross-organ regulatory relationships.
  • Causal links between lung function and brain neuronal activity require clarification.

Purpose of the Study:

  • To investigate the causal association between lung function and brain regional neuronal activity amplitude traits (NAATs).
  • Utilized Mendelian randomization to explore genetic links between lung function and brain activity.

Main Methods:

  • Employed univariable (UVMR) and multivariable Mendelian randomization (MVMR) analyses.
  • Utilized genome-wide association study summary data for lung function indicators (n=400,102) and brain NAATs (n=34,691).
  • Applied the inverse-variance weighted method for causal estimates and conducted sensitivity analyses.

Main Results:

  • Identified 23 causal associations in UVMR, including 21 for peak expiratory flow (PEF) and 2 for forced expiratory volume in 1 second (FEV1).
  • MVMR revealed eight causal associations between PEF and NAATs across various brain regions.
  • Significant associations were found between PEF and neuronal activity in the middle occipital gyrus, precuneus, middle frontal gyrus, and cerebellum.

Conclusions:

  • Demonstrated genetically predicted causal effects of PEF on brain neuronal activity.
  • Reduced PEF is associated with altered neuronal activity in specific brain regions.
  • Monitoring PEF may be crucial for early detection of brain dysfunction in lung disease patients.