Nilotinib-Induced Retinal Artery Thrombosis in a Patient With Chronic Myeloid Leukaemia: A Rare Case
Vahid Mohammadkarimi1, Abolfazl Khalafi-Nezhad1, Bijan Najafi2
1Hematology Research Center, Department of Hematology, Medical Oncology and Stem Cell Transplantation, Shiraz University of Medical Sciences, Shiraz, Iran.
Background:
Tyrosine kinase inhibitors (TKIs) used in chronic myeloid leukemia (CML) are associated with a spectrum of cardiovascular toxicities, including hypertension, atrial fibrillation, impaired cardiac function, heart failure, and arterio-occlusive events. Among these, nilotinib has been particularly linked to peripheral arterial disease and thromboembolic complications.
Case:
We report the case of a 53-year-old male patient who initially presented with fatigue, malaise, and mild left upper quadrant abdominal pain. Bone marrow aspiration confirmed CML with the presence of the BCR::ABL1 fusion gene. The patient was started on nilotinib therapy. After 8 months of treatment, he developed unilateral blurred vision and sixth nerve palsy, which were attributed to a retinal arterial occlusion. No prior cardiovascular risk factors were documented. Nilotinib therapy was discontinued, and the patient was switched to dasatinib, leading to gradual improvement of visual symptoms.
Conclusion:
This case underlines the importance of considering rare but severe arterio-occlusive complications, such as retinal artery thrombosis, among the cardiovascular toxicities of nilotinib. Careful cardiovascular monitoring and early recognition of such events are crucial to optimize patient safety and treatment outcomes in CML management.
