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Updated: Feb 19, 2026

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression
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Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression

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Tackling Sepsis Using Host Defense Peptides That Reduce Proinflammatory Cytokine Production.

Poornima G Wedamulla1, Suzana K Straus1

  • 1Department of Chemistry, University of British Columbia, 2036 Main Mall, Vancouver, British Columbia V6T 1Z1, Canada.

ACS Infectious Diseases
|February 17, 2026
PubMed
Summary
This summary is machine-generated.

Host defense peptides (HDPs) show therapeutic potential against sepsis, a life-threatening condition caused by infection. HDPs reduce inflammatory cytokines, offering a promising strategy to combat this global health challenge.

Keywords:
high mobility group box 1 (HMGB1)host defense peptides (HDPs)immunomodulationinnate immunitylipopolysaccharide (LPS)proinflammatory cytokinessepsis

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Area of Science:

  • Immunology
  • Microbiology
  • Pharmacology

Background:

  • Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection.
  • Key mediators include bacterial lipopolysaccharide (LPS) and the alarmin high mobility group box 1 (HMGB1).
  • Sepsis remains a leading cause of mortality worldwide.

Purpose of the Study:

  • To present the role of host defense peptides (HDPs) in mitigating sepsis.
  • To highlight the therapeutic potential of HDPs in managing sepsis-induced inflammation.

Main Methods:

  • Review of existing literature on HDPs and their mechanisms in sepsis.
  • Analysis of HDPs' immunomodulatory and bactericidal activities.

Main Results:

  • HDPs exhibit multimodal activities, including bactericidal and immunomodulatory effects.
  • HDPs can reduce the levels of pro-inflammatory cytokines associated with sepsis.
  • These properties suggest HDPs can counteract sepsis progression.

Conclusions:

  • Host defense peptides (HDPs) represent a promising therapeutic avenue for sepsis.
  • Their dual action offers a novel strategy to combat sepsis and its associated mortality.