Choroidal imaging biomarkers as predictors of recurrent central serous chorioretinopathy: A multicenter retrospective...

Central serous chorioretinopathy (CSCR) is usually self-limiting but recurs in 30-50% of cases. This study compares demographic, clinical, and imaging data between patients with and without recurrent CSCR to identify predictors of recurrence.

Baseline and follow-up data were collected from 277 eyes of 265 patients with acute CSCR. Patients were divided into recurrent or non-recurrent CSCR groups based on recurrence within three months of resolution. OCT biomarkers analyzed included central macular thickness (CMT), double-layered sign (DLS), subfoveal choroidal thickness (SFCT), neurosensory retinal detachment height (NSRD), Haller layer thickness (HVT), inner choroidal thickness (ICT), and choroidal vascularity index (CVI).

This study involved 265 patients with 277 eyes. The non-recurrent group comprised 157 patients (158 eyes), with 108 (119 eyes) in the recurrent group. Baseline mean CMT and ICT at follow-up were significantly greater in the non-recurrent group than in the recurrent group. Follow-up CMT and DLS heights were significantly greater in the recurrent group. Mean CVI was significantly greater in the non-recurrent group than the recurrent group at baseline and follow-up. In a multivariate logistic regression model, hypertension was significantly negatively associated with non-recurrent CSCR (OR = 0.449, 95% CI: 0.236-0.855, p = 0.015).

The non-recurrent group had significantly increased CMT at baseline but significantly decreased CMT and DLS height at follow-up. ICT was greater in the non-recurrent group compared to recurrent counterparts at follow-up. Mean CVI was greater in the non-recurrent group at both time points. Hypertension may be associated with disease recurrence.