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Related Experiment Video

Updated: Feb 19, 2026

Scleral Cross-linking Using Riboflavin and Ultraviolet-A Radiation for Prevention of Axial Myopia in a Rabbit Model
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ROLE OF INFLAMMATION IN ATROPHY DEVELOPMENT AND PROGRESSION IN PATHOLOGIC MYOPIA.

Noa Gilead1,2, Yu Jeat Chong1,2, Joshua Lim1,2

  • 1Singapore National Eye Centre, Singapore.

Retina (Philadelphia, Pa.)
|February 17, 2026
PubMed
Summary
This summary is machine-generated.

Prior retinal inflammation accelerates atrophy progression in pathologic myopia. This inflammation is linked to more frequent multifocal involvement and a higher risk of incident atrophy, driving disease progression.

Keywords:
atrophyinflammationmacular myopic degenerationmacular neovascularizationmultifocal choroiditismyopiapatchy atrophypathologic myopiapunctate inner choroidopathy

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Area of Science:

  • Ophthalmology
  • Retinal Diseases
  • Myopia Research

Background:

  • Pathologic myopia is a leading cause of visual impairment.
  • Retinal inflammatory lesions, such as punctate inner choroidopathy, can occur in eyes with pathologic myopia.
  • The impact of prior retinal inflammation on the progression of atrophy in pathologic myopia is not fully understood.

Purpose of the Study:

  • To investigate the association between prior retinal inflammatory lesions and the rate of geographic atrophy progression in eyes with pathologic myopia.
  • To compare atrophy progression in eyes with a history of retinal inflammation versus non-inflamed myopic eyes.

Main Methods:

  • Retrospective case series analysis of 21 eyes with pathologic myopia and prior inflammatory lesions compared to 26 non-inflamed control eyes.
  • Primary outcome: annual atrophy-area change (mm2/year) assessed using multimodal imaging.
  • Secondary outcomes: incident/enlarging atrophy, multifocal vs. unifocal atrophy, and progression of Macular Edema, Traction, and Myopia (META-PM) categories.

Main Results:

  • Eyes with prior inflammation showed significantly faster patchy atrophy progression (0.76 mm2/year) compared to controls (0.38 mm2/year; P = 0.03).
  • Incident atrophy occurred in 100% of inflamed eyes versus 36.4% of controls (P < 0.01).
  • Inflammation was independently associated with faster atrophy expansion (β = 0.41 mm2/year; P = 0.033) and more frequent multifocal atrophy (71.4% vs. 23.1%; P < 0.01).

Conclusions:

  • Prior retinal inflammation is an independent risk factor for accelerated and multifocal atrophy progression in pathologic myopia.
  • Inflammation, beyond mechanical factors, plays a crucial role in driving atrophic changes in the macula of myopic eyes.
  • These findings highlight the importance of considering inflammatory history in managing patients with pathologic myopia and associated atrophy.