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Predictive value of a phenylephrine-guided resection algorithm in optimizing eyelid symmetry following bilateral
Mehmet Goksel Ulas1, Efe Koser2, Ayse Cetin Efe2
1Department of Ophthalmology, University of Health Sciences, Beyoglu Eye Training and Research Hospital, Istanbul, Turkey. mg_ulas@hotmail.com.
International Ophthalmology
|February 17, 2026
Summary
Phenylephrine-guided Müller muscle-conjunctival resection (MMCR) effectively corrects mild-to-moderate ptosis, achieving excellent eyelid symmetry. This approach accounts for Hering
Area of Science:
- Ophthalmology
- Surgical Techniques
- Eyelid Surgery
Background:
- Mild-to-moderate ptosis can affect eyelid symmetry and visual function.
- Hering's phenomenon, the equal innervation of yoke muscles, can complicate bilateral ptosis repair.
- Accurate preoperative assessment is crucial for optimizing surgical outcomes in ptosis correction.
Purpose of the Study:
- To evaluate the anatomical, functional, and aesthetic outcomes of phenylephrine-guided bilateral Müller muscle-conjunctival resection (MMCR).
- To assess the efficacy of a standardized resection algorithm accounting for Hering's phenomenon in optimizing eyelid symmetry.
- To determine the predictability and safety of this technique for mild-to-moderate ptosis.
Main Methods:
- Retrospective clinical study of patients with mild-to-moderate ptosis and good levator function.
- Simultaneous bilateral MMCR performed using a phenylephrine-based resection algorithm.
- Preoperative and postoperative evaluation of best-corrected visual acuity (BCVA) and margin reflex distance-1 (MRD-1) at 1 and 3 months.
Main Results:
- Significant improvement in MRD-1 observed postoperatively in both eyes (p < 0.001).
- Excellent or satisfactory eyelid symmetry achieved in 94.9% of patients.
- Revision surgery was required in only 8.4% of cases.
Conclusions:
- Phenylephrine-guided bilateral MMCR with a standardized algorithm is a safe and effective method for correcting mild-to-moderate ptosis.
- The technique allows for accurate bilateral surgical planning in a single session by accounting for Hering's phenomenon.
- This approach offers a predictable and potentially less invasive alternative for ptosis repair, improving eyelid symmetry.

