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Related Concept Videos

Assessment of the Rectum and Anus01:25

Assessment of the Rectum and Anus

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Evaluating the rectum and anus plays a crucial role in conducting a thorough physical examination of the gastrointestinal system. Although it may be uncomfortable and often embarrassing for the patient, it holds immense diagnostic value, particularly in detecting gastrointestinal diseases and abnormalities. This guide will explain how to perform this assessment using inspection and palpation methods.
Rectal Inspection
Begin by inspecting the perianal and anal areas for color, texture, rashes,...
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Sessile Serrated Lesion Detection Rate and Colorectal Cancer Risk and Mortality.

Edward S Huang1, Qiwen Huang2, Pragati Kenkare2

  • 1Department of Gastroenterology, Palo Alto Medical Foundation, Sutter Health, San Jose, California.

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|February 17, 2026
PubMed
Summary
This summary is machine-generated.

Higher sessile serrated lesion detection rates (SSLDR) in colonoscopies correlate with a reduced risk of postcolonoscopy colorectal cancer (PCCRC). This study suggests SSLDR is a vital quality metric for colonoscopy effectiveness.

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Area of Science:

  • Gastroenterology
  • Oncology
  • Public Health

Background:

  • The adenoma detection rate (ADR) is a standard colonoscopy quality metric.
  • Benchmarks for detecting and removing serrated polyps, specifically the sessile serrated lesion detection rate (SSLDR), are lacking.

Purpose of the Study:

  • To evaluate the association between physician SSLDR and the risk of postcolonoscopy colorectal cancer (PCCRC).
  • To assess the relationship between SSLDR and PCCRC-related mortality.

Main Methods:

  • Retrospective cohort study of 328,416 colonoscopies from 2000-2021 in Northern California.
  • Patients aged 18+ without prior CRC, IBD, or CRC diagnosis within 6 months of colonoscopy.
  • SSLDR categorized into quartiles; PCCRC and mortality outcomes ascertained via cancer registries and vital records.

Main Results:

  • A higher SSLDR was associated with a dose-dependent decrease in PCCRC risk.
  • The highest SSLDR quartile showed a 31% lower risk of PCCRC compared to the lowest quartile (HR, 0.69; P=.01).
  • Higher SSLDR was linked to reduced all-cause and CRC-related mortality, particularly in the second and third quartiles.

Conclusions:

  • A higher physician SSLDR is significantly associated with a lower risk of PCCRC.
  • These findings support the implementation of SSLDR as a critical quality indicator for colonoscopy.
  • Improving SSLDR may enhance colonoscopy effectiveness in preventing colorectal cancer.