First Comprehensive Characterization of Lip Lymphoma: A Population-Based Study.

Area of Science:

• Oncology
• Hematology
• Epidemiology

Background:

• Lip lymphoma is an exceptionally rare extranodal lymphoma.
• Limited data exists to guide clinical management for lip lymphoma.
• This study provides the first large-scale population-based analysis of lip lymphoma.

Purpose of the Study:

• To characterize the epidemiology of lip lymphoma.
• To analyze treatment patterns for lip lymphoma.
• To determine outcomes and prognostic factors for lip lymphoma.

Main Methods:

• Utilized the SEER database (2000-2022) to identify lip lymphoma cases.
• Categorized patients into localized primary lip lymphoma (LPLL, stage I) and lymphoma involving the lip area (LIL, stages II-IV).
• Performed survival analysis and multivariate analysis to identify prognostic factors.

Main Results:

• Identified 82 lip lymphoma cases with an age-adjusted incidence of 0.0459 per million per year.
• MALT lymphoma was the most common histology (46.3%).
• Ten-year overall survival was 72.7% and cancer-specific survival was 92.6%, with age and non-low-grade histology predicting survival.

Conclusions:

• Lip lymphoma demonstrates an excellent prognosis, particularly for low-grade B-cell histologies.
• Age and histological grade are principal prognostic factors.
• Treatment strategies did not show significant survival superiority, suggesting prognosis is primarily histology-dependent.