Comparable survival after lobectomy and total thyroidectomy for T3b differentiated thyroid carcinoma: A...

The 2025 American Thyroid Association guidelines recommend total thyroidectomy for all T3b differentiated thyroid carcinoma (DTC). However, the prognostic impact of the surgical extent remains inadequately characterized. This study evaluated the association between surgical approach and survival outcomes in T3b DTC.

We analyzed 6,920 T3b DTC patients (2004-2022) from the Surveillance, Epidemiology, and End Results (SEER) database (total thyroidectomy, n = 6,638; lobectomy, n = 282). Variable importance was assessed using SHAP values and permutation methods derived from Random Survival Forest models. The association between surgical approach and overall survival (OS) was evaluated using multivariable Cox regression. Stratified survival analyses were performed by tumor size (≤20 mm, 20-40 mm, >40 mm) and nodal status (N0, N1a, N1b). Sensitivity analyses were conducted using disease-specific survival as an alternative endpoint, with Fine-Gray models employed to account for competing non-thyroid cancer mortality.

Variable importance analysis revealed that surgical approach minimally predicted outcomes (SHAP: 1.5%; permutation: 1.8%), ranking below age (43.1-55.8%), tumor size (21.2-22.2%), and nodal status (5.5-11.4%). Lobectomy showed equivalent survival to total thyroidectomy (adjusted HR 0.96, 95% CI 0.68-1.37; 10-year OS 89.9% vs 89.6%, difference - 0.3%). Survival equivalence was consistent across all tumor size and nodal status subgroups, with favorable-risk patients (tumors ≤ 40 mm, N0) achieving disease-specific survival > 96% in both groups.

These findings suggest that surgical extent has minimal impact on survival in T3b DTC. Lobectomy may be an appropriate option for selected patients, supporting individualized rather than universal total thyroidectomy.