Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Treatment Resistant Cancers

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Operationalizing AD Biomarker Return of Research Results: Methods from the KU ADRC.

Biopreservation and biobanking·2026

Same author

ASO Author Reflections: Increasing Breast Conserving Therapy Rates with Multidisciplinary Clinic-Timing of Consultations is Key.

Annals of surgical oncology·2026

Same author

ASO Visual Abstract: Does Multidisciplinary Clinic Impact Rates of Breast Conserving Therapy?

Annals of surgical oncology·2026

Same author

Surgical trailblazers: Charting the course for first generation students interested in surgery.

American journal of surgery·2026

Same author

Circulating tumor cells as predictive biomarkers in the risk stratification of DCIS: Evidence of early dissemination.

Science advances·2025

Same author

Discordance of Perception and Experience of Trauma Surgeons and Their Families.

Journal of the American College of Surgeons·2025

Search research articles

Related Experiment Video

Updated: Feb 19, 2026

Single-Port Robotic-assisted Transaxillary Breast-conserving Surgery: A Prospective, Single-arm, Non-randomized Phase IIa Clinical Trial

Single-Port Robotic-assisted Transaxillary Breast-conserving Surgery: A Prospective, Single-arm, Non-randomized Phase IIa Clinical Trial

Published on: August 19, 2025

Does Multidisciplinary Clinic Impact Rates of Breast Conserving Therapy?

Tara Chandran¹, Jamie L Wager^1,2, Karam Obeid¹

¹Division of Breast Surgical Oncology, Department of Surgery, University of Kansas Medical Center, Kansas City, KS, USA.

Annals of Surgical Oncology

|February 17, 2026

Summary

Multidisciplinary clinics (MDC) including radiation oncologists (RO) significantly increase breast conservation therapy (BCT) rates. Integrating RO into MDC consultations enhances patient education and shared decision-making for eligible breast cancer patients.

More Related Videos

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

Endoscopic Bilateral Nipple-sparing Mastectomy via a Single Axillary Incision with Immediate Pre-pectoral Implant-based Breast Reconstruction

Endoscopic Bilateral Nipple-sparing Mastectomy via a Single Axillary Incision with Immediate Pre-pectoral Implant-based Breast Reconstruction

Published on: May 17, 2024

Related Experiment Videos

Last Updated: Feb 19, 2026

Single-Port Robotic-assisted Transaxillary Breast-conserving Surgery: A Prospective, Single-arm, Non-randomized Phase IIa Clinical Trial

Single-Port Robotic-assisted Transaxillary Breast-conserving Surgery: A Prospective, Single-arm, Non-randomized Phase IIa Clinical Trial

Published on: August 19, 2025

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

Endoscopic Bilateral Nipple-sparing Mastectomy via a Single Axillary Incision with Immediate Pre-pectoral Implant-based Breast Reconstruction

Endoscopic Bilateral Nipple-sparing Mastectomy via a Single Axillary Incision with Immediate Pre-pectoral Implant-based Breast Reconstruction

Published on: May 17, 2024

Area of Science:

Oncology
Surgical Oncology
Radiation Oncology

Background:

Factors influencing breast conservation therapy (BCT) rates are known, but the impact of multidisciplinary clinics (MDC) remains undocumented.
This study investigated the association between MDC composition and BCT rates in breast cancer patients.

Purpose of the Study:

To determine if multidisciplinary clinic (MDC) consultations, particularly those including surgical and radiation oncologists, impact breast conservation therapy (BCT) rates.
To compare BCT rates among different MDC configurations and BSO-only consultations.

Main Methods:

Retrospective chart review of 2023 stage 0-III breast cancer patients offered BCT.
Patients were categorized into four cohorts based on initial consultation: three-provider MDC (BSO, MO, RO), BSO+RO in MDC, BSO+MO in MDC, and BSO only.
Statistical analyses (Wilcoxon Rank Sum, Chi-Square/Fisher's Exact tests) compared BCT versus mastectomy rates.

Main Results:

Initial consultation type significantly affected BCT rates (p = 0.015).
Highest BCT rates were observed in three-provider MDC (89%) and BSO+RO in MDC (86%).
Lower BCT rates were noted for BSO+MO in MDC (78%) and BSO alone (77%) cohorts, highlighting the importance of RO inclusion.

Conclusions:

Multidisciplinary clinic (MDC) consultations including radiation oncologists (RO) are linked to higher breast conservation therapy (BCT) rates.
Wider adoption of MDCs incorporating RO alongside breast surgical oncology (BSO) can potentially increase BCT acceptance.
Enhanced patient education and shared decision-making within MDCs contribute to improved BCT outcomes.