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Postnatal reduction of eIF4E overexpression in D1-SPNs ameliorates KCNQ channel dysfunction, hyperexcitability and

Alina Aaltonen1, Ayu Tamaki1, Andrés Peris Ramón1

  • 1Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden.

Cellular and Molecular Life Sciences : CMLS
|February 17, 2026
PubMed
Abstract

No abstract available in PubMed .

Keywords:
Autism spectrum disorderD1 spiny projection neuronsEIF4E,KCNQ potassium channelsMmouse modelNeuronal excitabilityStriatumTranslational control

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Autism Spectrum Disorder01:19

Autism Spectrum Disorder

Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.