Iodine-Induced Sialadenitis Requiring Intubation After Intracranial Venous Sinus Stenting: A Case Report

BACKGROUND Iodine-induced sialadenitis (iodine-induced mumps), first described in 1956, has been reported in more than 100 cases in the medical literature. It involves acute swelling of the salivary glands, resembling the effects of the mumps virus, after administration of iodine-containing compounds. It is most commonly observed after iodinated contrast administration, although the exact pathophysiology remains unclear. CASE REPORT A 37-year-old woman underwent a cervical-cerebral angiogram, followed by venous sinus stenting 1 week later for idiopathic intracranial hypertension. Approximately 3 h after the procedure, she developed painful, unilateral swelling of the right parotid and submandibular glands. Because of progressively worsening respiratory distress, she required intubation and mechanical ventilation for 3 days. Imaging confirmed clinically significant soft-tissue swelling. Treatment included corticosteroids and supportive care, which resulted in complete symptom resolution. Allergy testing after discharge revealed selective hypersensitivity to the iopamidol contrast agent, with no reaction to iohexol. CONCLUSIONS This case illustrates a rare but potentially life-threatening instance of iodine-induced mumps in a patient without renal impairment. Most cases are self-limiting, but this report underscores the importance of recognizing airway compromise as a serious complication. Clinicians should maintain a high index of suspicion for this condition when patients present with acute salivary gland swelling after contrast exposure. Increased awareness may guide safer imaging practices and reduce unnecessary diagnostic procedures.