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Updated: Feb 19, 2026
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Recent Advances in Bioactive Flavonoids-based Nanotherapeutics as Promising Neuroprotectants in Epilepsy.
Priyabrata Pradhan1, Koushik Jana2, Somnath Ghosh2
1School of Pharmaceutical Sciences, Siksha 'O' Anusandhan (Deemed to be University), Kalinga Nagar, Bhubaneswar, Odisha, 751030, India.
Current Aging Science
|February 18, 2026
Summary
Flavonoids show neuroprotective effects against epilepsy by modulating neurotransmitters and reducing inflammation. These natural compounds offer a promising, low-cost alternative to traditional anti-epileptic drugs, with ongoing research enhancing their delivery.
Area of Science:
- Neuroscience
- Pharmacology
- Biochemistry
Background:
- Epilepsy is a neurological disorder characterized by seizures, stemming from abnormal brain electrical activity.
- Pathogenesis involves genetic, environmental, and lifestyle factors leading to neuronal degeneration.
- Current anti-epileptic drugs (AEDs) face limitations like drug resistance, side effects, and high costs.
Purpose of the Study:
- To explore the neuroprotective mechanisms of flavonoids in epilepsy.
- To evaluate flavonoids as potential alternatives to conventional AEDs.
- To highlight the role of flavonoid-based nanotherapeutics in epilepsy treatment.
Main Methods:
- Review of scientific literature on epilepsy pathogenesis and flavonoid mechanisms.
- Analysis of how flavonoids modulate neurotransmitter systems (glutamate, GABA) and receptor pathways (NMDA, AMPA).
- Examination of antioxidant and anti-inflammatory effects of various flavonoids.
Main Results:
- Flavonoids, including quercetin, rutin, and apigenin, demonstrate neuroprotective effects in experimental epilepsy models.
- These compounds reduce oxidative stress, neuroinflammation, and modulate neuronal excitability.
- Flavonoids act as multi-targeted agents, offering accessible and cost-effective therapeutic potential.
Conclusions:
- Flavonoids possess significant neuroprotective properties beneficial for epilepsy treatment.
- Flavonoid-based nanotherapeutics show promise for enhanced delivery and efficacy.
- Further research and development are crucial for optimizing flavonoids as epilepsy therapeutics.
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