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Multimodal Modulation of the IL-17 Axis: Integrating Small-Molecule Inhibition, PEGylation, and Targeted Nanoparticle
Anna C Renner1, Robert B Kargbo2
1North Dakota State University, Fargo, North Dakota 58108-6050, United States.
Abstract:
Recent patent disclosures reveal convergent strategies to modulate IL-17-driven pathology through complementary chemical and delivery modalities. Acidic small-molecule inhibitors, PEGylated derivatives, and antibody-functionalized lipid nanoparticles collectively address potency, exposure, and immune context. Together, these approaches outline an integrated framework for treating inflammatory diseases and immunosuppressive tumor microenvironments.
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