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Updated: Feb 19, 2026

Author Spotlight: Evaluating Biophysical Assays for Characterizing PROTACS Ternary Complexes
Published on: January 12, 2024
PROTACs for Collateral Degradation: Is It Time to Back Up the Bus?
Zhe Gavin Gao1, Kevin Burgess1
1Department of Chemistry, Texas A & M University, Box 30012, College Station, Texas 77842, United States.
Abstract:
Off-target effects are usually undesirable in drug development, but for some PROTACs and other degraders, they may be advantageous. Specifically, this can be so when the activities of multiprotein complexes are more important than just the targeted protein of interest.
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