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Updated: Feb 19, 2026

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
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Discovery and Preclinical Evaluations of Potent, Selective, and Allosteric Covalent WRN Inhibitors with Improved PK

Zhaobing Xu1,2, Qi Xiao1,2, Yong Liu1,2

  • 1Hubei Bio-Pharmaceutical Industrial Technological Institute Inc., No. 666 High Tech Avenue, East Lake High Tech Development Zone, Wuhan, Hubei 430075, China.

ACS Medicinal Chemistry Letters
|February 18, 2026
PubMed

Keywords:
Allosteric covalent inhibitorFluorinated vinyl sulfoneMicrosatellite instability-high (MSI-H)Pharmacokinetic propertiesWerner syndrome helicase (WRN)

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