Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hallucinogens and Psychedelics01:27

Hallucinogens and Psychedelics

771
Hallucinogens are psychoactive substances that profoundly alter perceptual experiences, generating unreal visual and sensory images. Often referred to as psychedelic drugs — a term derived from the Greek words "psyche" (mind) and "delos" (revealing) — these substances include marijuana and lysergic acid diethylamide (LSD), among others. These drugs vary in intensity and effects.
Marijuana, derived from the dried leaves and flowers of the hemp plant, contains...
771
CNS Stimulants: Psychedelic Agents01:22

CNS Stimulants: Psychedelic Agents

855
Hallucinogens, also known as psychedelic drugs, are a class of substances known for their ability to alter perception, cognition, and emotions. Despite their profound effects on the mind, these drugs are non-addictive, setting them apart from many other abused substances. The mechanism of action of these drugs lies in their impact on the 5-HT2A receptor in the brain. Upon activation, this receptor couples to Gq-type G proteins, triggering a cascade that releases intracellular calcium. This...
855
Modified-Release Drug Delivery Systems: Stimuli-Activated01:30

Modified-Release Drug Delivery Systems: Stimuli-Activated

26
Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also...
26

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Targeted Protein Degradation and Metabolic Inhibition as Complementary Therapeutic Strategies: TEAD PROTACs and NAT8L Inhibitors in Oncology.

ACS medicinal chemistry letters·2026
Same author

Degrading Immune Checkpoints and Coordinating Oncogenic Signaling: Emerging Strategies in Cancer Therapy.

ACS medicinal chemistry letters·2026
Same authorSame journal

Degradation and Detection: Integrating BCL6 Targeted Protein Degradation with Biomarker-Guided BET Inhibition in Cancer.

ACS medicinal chemistry letters·2026
Same authorSame journal

Controlling Neuroplasticity Across Scales: Constrained Serotonergic Agonists, Neuroplastogens, and Adaptive Neuromodulation.

ACS medicinal chemistry letters·2026
Same author

Acyclic Glutarimide PROTAC Precursors Enable Controlled Protein Degradation and Expand Cereblon Ligand Space.

ACS medicinal chemistry letters·2026
Same author

Selective Induction of Estrogen Receptor-Dependent Stress Signaling as a Therapeutic Strategy in Resistant Breast Cancer.

ACS medicinal chemistry letters·2026
Same journal

Semisynthesis of Mycothiazole Analogs having Distinct Bioactivity.

ACS medicinal chemistry letters·2026
Same journal

Investigation on the Cytotoxicity of Hydroxycinnamic and Hydroxybenzoic Acid-Based Natural Antioxidant Conjugated Terpyridine Analogues toward Triple-Negative Breast Cancer.

ACS medicinal chemistry letters·2026
Same journal

Beyond Neddylation Inhibition: X‑ray Structures Reveal Carbonic Anhydrase Isoform Selectivity of Pevonedistat.

ACS medicinal chemistry letters·2026
Same journal

Structure-Guided Discovery of Selective Polo-Like Kinase 3 Inhibitors.

ACS medicinal chemistry letters·2026
See all related articles

Related Experiment Video

Updated: Feb 19, 2026

Reproducible Manufacturing of SPOT as a High-throughput Scaffold-based Culture Platform
06:22

Reproducible Manufacturing of SPOT as a High-throughput Scaffold-based Culture Platform

Published on: July 29, 2025

980

From Solid-State Control to Predictive Precision: Building a Deployable Ecosystem for Psychedelic Therapeutics.

Anna C Renner1, Robert B Kargbo2

  • 1North Dakota State University, Fargo, North Dakota 58108-6050, United States.

ACS Medicinal Chemistry Letters
|February 18, 2026
PubMed
Summary
This summary is machine-generated.

Psychedelic drug development is advancing with new therapeutic systems. Innovations include optimizing drug stability and using AI to predict patient responses, addressing key challenges in psychedelic medicine.

Area of Science:

  • Pharmacology
  • Neuroscience
  • Biotechnology

Background:

  • Psychedelic drug development is evolving beyond traditional molecular and experiential approaches.
  • Translational research faces bottlenecks in manufacturing, stability, and predicting therapeutic efficacy.

More Related Videos

Generating Controlled, Dynamic Chemical Landscapes to Study Microbial Behavior
10:07

Generating Controlled, Dynamic Chemical Landscapes to Study Microbial Behavior

Published on: January 31, 2020

6.7K
Robotic Sensing and Stimuli Provision for Guided Plant Growth
08:02

Robotic Sensing and Stimuli Provision for Guided Plant Growth

Published on: July 1, 2019

8.6K

Related Experiment Videos

Last Updated: Feb 19, 2026

Reproducible Manufacturing of SPOT as a High-throughput Scaffold-based Culture Platform
06:22

Reproducible Manufacturing of SPOT as a High-throughput Scaffold-based Culture Platform

Published on: July 29, 2025

980
Generating Controlled, Dynamic Chemical Landscapes to Study Microbial Behavior
10:07

Generating Controlled, Dynamic Chemical Landscapes to Study Microbial Behavior

Published on: January 31, 2020

6.7K
Robotic Sensing and Stimuli Provision for Guided Plant Growth
08:02

Robotic Sensing and Stimuli Provision for Guided Plant Growth

Published on: July 1, 2019

8.6K