Cross-sectional study on the relationship between sarcopenia indicators and lung function in a community-dwelling...

Area of Science:

• Gerontology and Respiratory Medicine
• Musculoskeletal Health and Aging

Background:

• Aging leads to degenerative changes in multiple body systems, including muscular and respiratory functions.
• While the link between sarcopenia and lung function is known in respiratory diseases, it's less understood in the general population.

Purpose of the Study:

• To investigate the relationship between sarcopenia indicators and lung function in a community-dwelling population.
• To explore the association between sarcopenia and different spirometry statuses.

Main Methods:

• Data on demographics, biochemical parameters, handgrip strength (HGS), gait speed (GS), 5 times sit-to-stand test (5STS), skeletal muscle mass index (SMI), and lung function were collected from 2,526 community volunteers.
• Linear and logistic regression analyses were used to examine relationships between sarcopenia indicators and lung function parameters and statuses.

Main Results:

• Positive correlations were found between HGS, GS, SMI and lung function parameters (FEV1, FVC).
• Negative correlation was observed between 5STS time and FEV1/FVC ratio.
• Lower HGS, slower GS, and longer 5STS time were associated with increased risks of preserved ratio impaired spirometry (PRISm) and obstructive spirometry.

Conclusions:

• Sarcopenia indicators are significantly associated with impaired lung function in community-dwelling individuals.
• Early identification and management of sarcopenia in community settings may offer multi-organ benefits, impacting healthy aging, quality of life, and longevity.