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Published on: December 5, 2025
Critical Events in Anaesthetised Kids Undergoing Tracheal Intubation (CRICKET)-study protocol for an international
Tom Bennett1, Nicola Disma2, Thomas Engelhardt3
1Department of Anaesthetics, University Hospital Southampton, Southampton, UK.
Insights
The Critical Events in Anaesthetised Kids undergoing Tracheal Intubation (CRICKET) study tracks critical events during pediatric tracheal intubation. This international research aims to improve airway management safety in children by analyzing event incidence and patient data.
Area of Science:
- Pediatric Anesthesiology
- Airway Management
- Patient Safety
Background:
- The Critical Events in Anaesthetised Kids undergoing Tracheal Intubation (CRICKET) study is a global initiative.
- It focuses on tracheal intubation events in pediatric patients.
Purpose of the Study:
- To capture, assess, and analyze critical events during tracheal intubation in children.
- To improve the safety of pediatric airway management.
Main Methods:
- Prospective, international multicenter observational study.
- Involves pediatric patients aged 0-16 years requiring tracheal intubation.
- Data collected via electronic case report forms, with detailed follow-up for critical events.
Main Results:
- The study began in January 2024 and is ongoing.
- As of May 2025, approximately 25,000 patients have been enrolled.
- An estimated 50,000 patients are expected by the end of 2025.
Conclusions:
- The primary outcome is the incidence of critical events during pediatric tracheal intubation.
- Further analysis depends on resources and observed event rates.
- Findings will inform strategies to enhance safety in pediatric airway procedures.
Background:
Critical Events in Anaesthetised Kids undergoing Tracheal Intubation (CRICKET) is a prospective, international multicentre observational study with the objective of capturing, assessing, and analysing critical events associated with tracheal intubation in children.
Methods:
CRICKET involves paediatric patients aged 0-16 yr, requiring tracheal intubation, performed by the anaesthesia team for procedures or interventions requiring general anaesthesia, either planned or unplanned. Patient characteristics and airway management techniques are recorded using a dedicated electronic case report form. If one or more critical events associated with airway management occur, a second, more detailed questionnaire will be completed for the follow-up until the patient is discharged or up to a maximum of 30 days. We aim to include 105 000 patients from participating centres disseminated worldwide. Every participating centre collects data over a consecutive observational period of 3 months. The primary outcome is the incidence of critical events associated with tracheal intubation in children.
Results:
The CRICKET study started in January 2024 and is currently ongoing. By May 2025, around 25 000 patients were entered into the database, with an estimated 50 000 patients by the end of 2025. Because of the observational nature of the study and the extensive international involvement and effort, continuing the study or analysing the existing data will depend on available resources and exact incidence of critical events.
Funding:
This work was supported by the Italian Ministry of Health (Ricerca Corrente 2025).
Clinical Trial Registration:
ClinicalTrials.gov (NCT05804188).
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