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Removal and Replacement of Endogenous Ligands from Lipid-Bound Proteins and Allergens
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Removal and Replacement of Endogenous Ligands from Lipid-Bound Proteins and Allergens

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Calcium-binding proteins as allergens.

Andrea O'Malley1, Kriti Khatri1, Elaine M Wright1

  • 1Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI, United States.

Frontiers in Allergy
|February 18, 2026
PubMed
Summary
This summary is machine-generated.

Calcium-binding proteins, like parvalbumins, are common allergens in foods and inhaled substances. Their widespread presence and cross-reactivity make them challenging to avoid, impacting both food and respiratory allergies.

Keywords:
EF-handIgEallergencalciumcross-reactivitystability

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Area of Science:

  • Biochemistry
  • Immunology
  • Allergology

Background:

  • Calcium-binding proteins, especially EF-hand proteins, are vital for calcium transport and storage.
  • These proteins are prevalent across various biological systems.
  • Allergens within these families are significant contributors to allergic diseases.

Purpose of the Study:

  • To review allergens belonging to the parvalbumin, polcalcin, sarcoplasmic calcium-binding protein, and troponin C families.
  • To discuss the characteristics of these calcium-binding protein allergens.
  • To highlight their role in various allergic conditions.

Main Methods:

  • Literature review of studies focusing on calcium-binding proteins and allergies.
  • Analysis of IgE reactivity and cross-reactivity patterns.
  • Identification of implicated protein families and allergen sources.

Main Results:

  • Allergens from parvalbumin, polcalcin, sarcoplasmic calcium-binding protein, and troponin C families exhibit diverse IgE reactivity.
  • Significant cross-reactivity exists among these allergens.
  • These allergens are implicated in both inhaled and food allergies.

Conclusions:

  • Calcium-binding proteins are significant allergens due to their ubiquitous nature.
  • Their cross-reactivity poses challenges for diagnosis and avoidance strategies.
  • Understanding these allergens is crucial for managing food and inhaled allergies.