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Neurogenesis and Regeneration of Nervous Tissue

Neurogenesis and Regeneration of Nervous Tissue

In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...

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Related Experiment Video

Updated: Feb 19, 2026

A Proinflammatory, Degenerative Organ Culture Model to Simulate Early-Stage Intervertebral Disc Disease.

A Proinflammatory, Degenerative Organ Culture Model to Simulate Early-Stage Intervertebral Disc Disease.

Published on: February 14, 2021

Neuroregulatory Biomaterials for Intervertebral Disc Regeneration via Neuro-Disc Microenvironment Modulation.

Ang Li¹, Xiaohu Li¹, Yi Yu¹

¹Department of Orthopedics, Yangpu Hospital, School of Medicine, Tongji University, Shanghai 200090, China.

Research (Washington, D.C.)

|February 18, 2026

Summary

This summary is machine-generated.

Intervertebral disc degeneration involves nerve invasion, exacerbating pain via neural-microenvironment interactions. This review explores neural regulation and bioengineering for intervertebral disc repair and regeneration therapies.

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Anatomically Inspired Three-dimensional Micro-tissue Engineered Neural Networks for Nervous System Reconstruction, Modulation, and Modeling

Anatomically Inspired Three-dimensional Micro-tissue Engineered Neural Networks for Nervous System Reconstruction, Modulation, and Modeling

Published on: May 31, 2017

Area of Science:

Biomedical Engineering
Neuroscience
Regenerative Medicine

Background:

Intervertebral discs were historically considered aneural.
Pathological nerve invasion is now recognized in disc degeneration.
Neural-microenvironment interactions significantly worsen degeneration and pain.

Purpose of the Study:

To systematically analyze the role of neural-microenvironment interactions in intervertebral disc degeneration.
To review bioengineering strategies for treating disc degeneration.
To explore neural-regulated biomaterials for regenerative therapy.

Main Methods:

Discussion of neural innervation in healthy and degenerated discs.
Elaboration on mechanisms of abnormal nerve growth and pain pathways.
Review of bioengineering strategies and neural-regulated biomaterials.

Main Results:

Nerve invasion in degenerated discs activates pain pathways.
Bioengineering offers novel treatments via neural regulation and microenvironment modulation.
Neural-regulated biomaterials show promise for precision medicine.

Conclusions:

Understanding neural-microenvironment interactions is crucial for intervertebral disc repair.
Bioengineering and neural-regulated biomaterials offer innovative therapeutic avenues.
This review provides a basis for neural-based intervertebral disc regeneration.