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Patient Perspectives on Psychiatric Polygenic Risk Scores in Reproductive Decision-Making and Polygenic Embryo

Lauren A Ginn1, Amanda R Merner2,3,4, Page M Trotter1

  • 1Center for Medical Ethics and Health Policy, Baylor College of Medicine, Houston, Texas, USA.

American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics
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PubMed
Summary
This summary is machine-generated.

Half of adults with psychiatric conditions would use polygenic risk scores (PRS) for family planning and embryo screening. Patients desire improved child quality of life, but concerns exist about exacerbating mental illness stigma.

Keywords:
ethicsfamily planninggenetic testingpolygenic risk scorespsychiatryreproductive decisions

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Area of Science:

  • Psychiatry
  • Genetics
  • Reproductive Medicine

Background:

  • Polygenic risk scores (PRS) estimate genetic predisposition for multifactorial conditions.
  • Psychiatric PRS, developed from genome-wide association studies, offer potential for improved diagnosis and treatment.
  • Concerns about heritability of mental illness influence reproductive decisions for affected individuals.

Purpose of the Study:

  • To evaluate patient perspectives on the utility of psychiatric PRS in reproductive decision-making.
  • To explore potential benefits and risks associated with using psychiatric PRS for family planning and embryo selection.
  • To inform clinical and regulatory discussions regarding the application of psychiatric PRS in reproductive contexts.

Main Methods:

  • Conducted semi-structured interviews with adults diagnosed with psychiatric conditions (n=29).
  • Assessed participants' views on the potential benefits and risks of utilizing psychiatric PRS in reproductive choices.
  • Analyzed qualitative data to identify key themes and patient perspectives.

Main Results:

  • Approximately 50% of participants expressed interest in using psychiatric PRS for reproductive purposes, including family planning and in vitro fertilization (IVF) embryo screening.
  • Motivations for using psychiatric PRS included enhancing children's quality of life and parental empowerment.
  • Concerns were raised regarding the potential for psychiatric PRS to increase stigma associated with mental illness.
  • A majority indicated that the use of psychiatric PRS in reproductive decisions should be permissible for the general population.

Conclusions:

  • Patient perspectives reveal a divided interest in utilizing psychiatric PRS for reproductive decision-making.
  • Desires to improve offspring well-being are a key driver for potential adoption of psychiatric PRS.
  • Addressing concerns about stigma and ensuring equitable access are crucial for the responsible integration of psychiatric PRS in reproductive health.
  • Patient views are essential for guiding the future development and ethical implementation of psychiatric PRS in reproductive spaces.