The fun we had doing crosses with Neurospora wild and Dp strains

Dps and MSUD: Twenty-five years ago, Robert Metzenberg and colleagues discovered why a cross between a normal euploid Neurospora crassa strain and one carrying any chromosome segment duplication (N X Dp) was barren and produced only a few exceptional progeny ascospores. The culprit was a novel gene-silencing process, which they named meiotic silencing by unpaired DNA (MSUD; Cell 107, 905-916, 2001).