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Updated: May 4, 2026

Biomimetic Materials to Characterize Bacteria-host Interactions
Published on: November 16, 2015
Synthesis, characterisation and biological properties of a silver helicate which displays enhanced activity towards
Peltine Ndifon1, Emma C Pinder1, Christopher H L Slater1
1Department of Physical and Life Sciences, School of Applied Sciences, University of Huddersfield, Huddersfield, HD1 3DH, UK. m.whitehead@hud.ac.uk.
Abstract:
Antimicrobial resistance is an ever growing concern and the development of novel treatment methods is urgently required. In this study a novel bis-bidentate ligand strand which forms a dinuclear double helicate in solution with silver cations, [Ag2L2]2+ demonstrated cytotoxicity against a range of cancer cell lines and antimicrobial activity against bacterial pathogens E. coli, P. aeruginosa and S. aureus (a methicillin resistant strain; MRSA), with the latter being at least 8 times more sensitive to the helicate complex compared to silver cations on their own.
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