Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

MOF-Stabilized Pd Nanosheets With Exposed Active Crystal Planes for Efficient Hydrogen Evolution.

ChemSusChem·2026
Same author

Overall Water-Splitting Enabled by Bifunctional NiPd/Pd Heterodimer Fabricated via In Situ Etching-Growth Route.

Inorganic chemistry·2026
Same author

Synthesis and Optoelectronic Properties of Branched Polystyrene-<i>graft</i>-Polyfluorene Copolymers.

Micromachines·2026
Same author

Efficacy of dialectical behavior therapy-based interventions for individuals with autism spectrum disorder: a systematic review and meta-analysis.

BMC psychology·2026
Same author

Synthesis, Electron Transport Behavior, and Enhanced Blue Light Stability of Polyfluorene-Poly(Methyl Methacrylate) Diblock Copolymers.

Micromachines·2026
Same author

AI-Driven De Novo Binder Design: From Structure Prediction to Closed-Loop Optimization.

Computational and structural biotechnology journal·2026

Related Experiment Video

Updated: Feb 20, 2026

Trans-Tympanic Drug Delivery for the Treatment of Ototoxicity
09:52

Trans-Tympanic Drug Delivery for the Treatment of Ototoxicity

Published on: March 16, 2018

10.0K

Notoginsenoside R1 as a Protector Against Gentamicin Ototoxicity: Targeting p62-NRF2-GPX4 Ferroptosis Axis.

Xiaorui Chen1, Ruoyu Jiang2, Yunfeng Chu1

  • 1Zhangjiagang TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Nanjing, China.

Advanced Biology
|February 18, 2026
PubMed
Summary
This summary is machine-generated.

Notoginsenoside R1 effectively treats sudden sensorineural hearing loss (SSNHL) by inhibiting ferroptosis and oxidative stress. This compound activates the p62-NRF2 pathway, protecting cochlear hair cells and improving hearing function.

Keywords:
NRF2ferroptosisnotoginsenoside R1oxidative stresssudden sensorineural hearing loss

More Related Videos

Mechanism of Kemeng Fang's Inhibition of Podocyte Apoptosis in Rats with Membranous Nephropathy through the PI3K/AKT Signaling Pathway
07:15

Mechanism of Kemeng Fang's Inhibition of Podocyte Apoptosis in Rats with Membranous Nephropathy through the PI3K/AKT Signaling Pathway

Published on: August 23, 2024

972
Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics
04:01

Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics

Published on: March 15, 2024

2.0K

Related Experiment Videos

Last Updated: Feb 20, 2026

Trans-Tympanic Drug Delivery for the Treatment of Ototoxicity
09:52

Trans-Tympanic Drug Delivery for the Treatment of Ototoxicity

Published on: March 16, 2018

10.0K
Mechanism of Kemeng Fang's Inhibition of Podocyte Apoptosis in Rats with Membranous Nephropathy through the PI3K/AKT Signaling Pathway
07:15

Mechanism of Kemeng Fang's Inhibition of Podocyte Apoptosis in Rats with Membranous Nephropathy through the PI3K/AKT Signaling Pathway

Published on: August 23, 2024

972
Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics
04:01

Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics

Published on: March 15, 2024

2.0K

Area of Science:

  • Otorhinolaryngology
  • Neuroscience
  • Pharmacology

Background:

  • Sudden sensorineural hearing loss (SSNHL) is a common auditory disorder linked to oxidative stress and ferroptosis.
  • The therapeutic potential of Notoginsenoside R1, a Panax notoginseng component, in ferroptosis-related hearing loss is not well understood.

Purpose of the Study:

  • To investigate the protective effects and underlying mechanisms of Notoginsenoside R1 against SSNHL.
  • To evaluate Notoginsenoside R1's role in regulating ferroptosis and oxidative stress in auditory damage.

Main Methods:

  • Utilized a mouse model of SSNHL and an oxygen-glucose deprivation/reoxygenation (OGD/R)-induced HEI-OC1 cell model.
  • Assessed auditory brainstem response (ABR) thresholds, hair cell apoptosis, oxidative damage markers (Fe2+, ROS, MDA, LPO), and antioxidant enzymes (SOD, GSH, GCL, GPX4).
  • Employed target prediction, qPCR, molecular docking, and microscale thermophoresis (MST) to elucidate the p62-NRF2 pathway interaction.

Main Results:

  • Notoginsenoside R1 significantly improved hearing thresholds and reduced cochlear hair cell apoptosis in SSNHL mice.
  • The compound inhibited ferroptosis by decreasing oxidative stress markers and increasing antioxidant enzyme levels.
  • Notoginsenoside R1 directly interacted with p62, promoting NRF2 nuclear translocation and restoring downstream antioxidant gene expression.

Conclusions:

  • Notoginsenoside R1 demonstrates significant protective effects against SSNHL.
  • The mechanism involves the inhibition of ferroptosis and oxidative stress through the activation of the p62-NRF2-GCL-GPX4 signaling axis.
  • Notoginsenoside R1 represents a potential therapeutic agent for treating SSNHL.