[Problems of interpretation of clinical results of blood transfusion in the 19th century]
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Updated: Feb 20, 2026

A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy
M S Sergeeva1, T V Litvinova1, N N Krylov1
1Sechenov First Moscow State Medical University (Sechenov University).
In the 19th century, blood transfusions were performed according to broad indications, which makes it difficult to unify and standardize the nomenclature of previously used terms and concepts to determine the composition of patient groups. We collected and described 833 cases of intravenous blood injection for therapeutic purposes and compared the previously stated results with a modern hypothetical model of a likely favorable match of donor-recipient pairs according to the main immunological characteristics of blood, as well as studied the criteria underlying medical conclusions on the effectiveness of the procedure.
In the 19th century, blood transfusions were performed according to broad indications, which makes it difficult to unify and standardize the nomenclature of previously used terms and concepts to determine the composition of patient groups. We collected and described 833 cases of intravenous blood injection for therapeutic purposes and compared the previously stated results with a modern hypothetical model of a likely favorable match of donor-recipient pairs according to the main immunological characteristics of blood, as well as studied the criteria underlying medical conclusions on the effectiveness of the procedure.
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